Free Patten Neurological Differential Diagnosis Pdf Programs
Neurological Differential Diagnosis PDF John Patton's Neurological Differential Diagnosis was the first text of neurology I purchased, at the suggestion of my chief resident Dr. John Stiller while doing my required 3-month clerkship during my medical training inthe 1980's. Neurological Differential Diagnosis by John P. Patten, 373, available at Book Depository with free delivery worldwide.Missing.
Results Ninety-seven subjects’ records were used in the final analysis. The most common disease categories of misdiagnosis were neurodegenerative, autoimmune/paraneoplastic, infectious, and toxic/metabolic disorders. The most common individual misdiagnoses were viral encephalitis, paraneoplastic disorder, depression, vertigo, Alzheimer disease, stroke, unspecified dementia, central nervous system vasculitis, peripheral neuropathy, and Hashimoto encephalopathy. The physicians who most commonly made these misdiagnoses were primary care physicians and neurologists; in the 18% of patients who were diagnosed correctly at their first assessment, the diagnosis was almost always by a neurologist. The mean time from onset to diagnosis was 7.9 months, an average of two-thirds of the way through their disease course. There are often long Delays between the time that a patient with sporadic Jakob-Creutzfeldt disease (sCJD) first presents to the physician and the time that a correct diagnosis is made.
Sporadic CJD is misdiagnosed for many reasons, including the variability of early symptoms and signs, – the variability in disease duration, and lack of recognition of this condition in the medical community. Depending on where prions accumulate in the brain, the clinical presentation can be variable, and sCJD is easily mistaken for other neurodegenerative conditions such as Alzheimer disease, corticobasal degeneration, and dementia with Lewy bodies. – As a major center for referral of human prion diseases, we have noted that many of the families of patients with sCJD complain of the delay in diagnosis and the multitude of misdiagnoses that were given prior to sCJD being properly identified. This prompted our retrospective study to determine the most common early misdiagnoses, determine at what point in the disease course the correct diagnosis of sCJD was made, and identify which medical specialties were making the misdiagnoses. Expediting an sCJD diagnosis will help avoid potential infection control issues and extensive and costly evaluations for other conditions, allow families to focus on patient care and end-of-life planning, and facilitate early enrollment in ongoing and future treatment trials.
STUDY POPULATION AND DATA COLLECTION We received approval for this study from our institution’s internal review board. For this study, we retrospectively reviewed all cases referred to the UCSF Memory and Aging Center rapidly progressive dementia and CJD clinical research program between August 2001 and February 2007. This included patients initially assessed through our inpatient National Institutes of Health research unit, evaluated in our neurobehavioral clinic, or admitted to the inpatient neurology service or those who were not seen at University of California, San Francisco but who had extensive record review. Subjects were included in the study if they had pathology-proven sCJD and records included most or all of their physician and hospital visits; if only 1 or 2 visit summaries were missing, the records were still included unless the missing summaries included the patient’s first physician consultation.
Qualifying records were then reviewed to determine all non-CJD diagnoses considered up to when probable sCJD became the single most likely diagnosis or when the patient received a diagnosis at our center, whichever came first. Non-CJD diagnoses were given a confidence probability value on a Likert scale of 1 to 5 based on what we perceived from the record review the diagnosing physician’s diagnostic confidence level to be: 1 meant the diagnosis was considered most likely; 2, likely; 3, possible (but other conditions also possible); 4, unlikely; and 5, highly unlikely but wanted to rule it out. Only non-CJD diagnoses with a confidence probability value of 1 and 2 were used for this analysis. The time taken to make a diagnosis of sCJD was calculated for each subject. This was possible in 92 of 97 subjects with a documented first symptom date, diagnosis date, and date of death (date of first symptom not available for 3 and diagnosis date not available for 2 subjects). MISDIAGNOSES Our cohort of 97 patients with sCJD received a combined total of 373 alternative diagnoses prior to their diagnosis of likely CJD, with an average of 3.8 misdiagnoses per subject. The shows the 16 general diagnostic categories of misdiagnosis and their frequency in this cohort.
Neurodegenerative, autoimmune, infectious, toxic/metabolic, and unknown dementias were the categories under which patients with sCJD were most commonly misdiagnosed. Shows the 10 most common specific conditions misdiagnosed for CJD. Shows some of the common conditions found in each of the 5 most common (of 16) diagnostic categories.
Seventy-five percent of patients were initially assessed by either a primary care physician (40%) or a neurologist (36%). Most patients were first seen by their primary care physician and then referred to a neurologist. Only 25% of patients were first seen by a specialist other than a neurologist. The first specialists to see these 97 patients were neurologists (n=70), ophthalmologists (n=6), psychiatrists (n=4), cardiologists (n=4), otolaryngologists (n=2), orthopedists (n=2), and neuro-oncologists (n=1). The types of all physicians to see these patients prior to being given a diagnosis of likely sCJD (eg, diagnostic confidence category 1 or 2) are shown in; neurologists and internists comprised the vast majority of the physicians making the misdiagnoses.
Of the 17 subjects (18%) who received the correct diagnosis on first assessment, 16 of these correct diagnoses were made by neurologists and 1, by a rehabilitation physician. Shows the time taken for sCJD to be considered in the differential diagnosis and also the time then taken for the diagnosis of CJD to be made (“likely CJD”). COMMENT To our knowledge, this is the first large study of pathologically proven cases of sCJD that retrospectively determines what misdiagnoses are made in the workup of sCJD, who makes these misdiagnoses, and how long it takes to reach the correct diagnosis. We found that CJD is rarely the first diagnosis made and it is usually confused with a wide range of other conditions. It is not surprising that the top misdiagnoses categories were neurodegenerative, autoimmune/paraneoplastic, infectious, and toxic/metabolic conditions, as these are common forms of nonprion rapidly progressive dementia., That the most common individual misdiagnosis was viral encephalitis is probably due to the multifocality, acuity, and rapidity of symptoms seen in sCJD.
Despite a neurologist being the first specialist to see most patients with sCJD, there were many misdiagnoses, with each subject receiving almost 4 other diagnoses before CJD became the likely diagnosis. Consequently, subjects were diagnosed late, two-thirds of the way through their disease course. One possible reason misdiagnosis is so common is that the diagnostic criteria for sCJD are insensitive to early symptoms.
Whereas sCJD can only be definitively confirmed through pathology, there are a variety of probable CJD diagnostic criteria. – Most of these criteria were designed for epidemiologic surveillance purposes to diagnose sCJD post mortem in patients whose disease was not pathologically proven.
World Health Organization probable sCJD criteria rely heavily on the presence of cerebrospinal fluid 14-3-3 protein, the utility of which is dubious. – More recent research has found magnetic resonance imaging (MRI) findings to be more sensitive and specific than 14-3-3., Physicians relying on certain criteria might not properly include CJD in the differential diagnosis nor appreciate the value of diffusion-weighted imaging and apparent diffusion coefficient sequences that improve MRI sensitivity to around 91% to 96% – and specificity to around 91% to 95%. – Based on this study, if neurodegenerative, autoimmune, infectious, or toxic/metabolic etiologies appear on the list of differential diagnoses of a patient with a rapidly progressive dementia, then the clinician should also consider sCJD. Equally, if evidence to support a diagnosis of viral encephalitis, paraneoplastic disorder, depression, peripheral vertigo, Alzheimer disease, stroke, dementia (nonspecified), central nervous system vasculitis, peripheral neuropathy, or Hashimoto encephalopathy is lacking, then the clinician should think about requesting an MRI with diffusion-weighted imaging/apparent diffusion coefficient sequences to look for changes associated with sCJD. Unfortunately, even the pathognomonic MRI findings of CJD are missed by about two-thirds of radiology reports, and thus, it is critical that physicians be aware of MRI findings in prion disease and read their patients’ MRIs.
In any patient with a rapidly progressive dementia who has been given multiple potential diagnoses, sCJD must be considered. Although neurologists were more likely to make the correct diagnosis on first assessment than other physicians, this occurred uncommonly and neurologists were also the type of physician to most commonly assess these patients and therefore make misdiagnoses, followed by internists. Education about the diagnosis of CJD perhaps should focus on these 2 specialties.
About 25% of patients were first seen by a non-neurology specialist; education of these other specialists about early signs of sCJD might also improve earlier diagnosis. Although this current study focused on patients with sCJD being misdiagnosed with other conditions, the contrary—patients with non-CJD diagnoses being diagnosed with CJD—is equally, if not more, harmful, as many of these non-CJD rapidly progressive dementias are treatable if not even curable. Chitravas et al recently demonstrated that 32% of subjects referred to the US National Prion Disease Pathology Surveillance Center for autopsy with suspected CJD had a non-CJD diagnosis, and 7% of all cases had a treatable etiology.
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The experience in our center and other centers evaluating many rapidly progressive dementias is similar., Furthermore, subjects might fulfill clinical criteria, particularly symptom criteria, for more than 1 disease. In 1 study, patients with pathologically proven sCJD fulfilled the “probable” criteria for dementia with Lewy bodies (29%) and Alzheimer disease (45%). Similarly, in a recent article from our own group, we found 46% of subjects with sCJD met probable dementia with Lewy bodies criteria and 40% of subjects with dementia with Lewy bodies met probable CJD criteria. The value of a thorough diagnostic workup is therefore critical. Early and accurate diagnosis of sCJD is of value for public health reasons and to allow for potential treatments to be tested as early as possible in the disease course., Avoiding iatrogenic transmission of human prion disease by early diagnosis is also critical., It would therefore be valuable to improve early and accurate diagnosis of sCJD premortem to identify at-risk persons, allowing for public health measures that would prevent transmission to healthy individuals through blood donation, infected surgical equipment, and or other medical procedures. Funding/Support: This study was supported by National Institute on Aging grants K23AG021989, P01-AG021601, R01-AG031189, and P50-AG023501, National Institutes of Health National Institute of Neurological Disorders and Stroke contract N01-NS-0-2328, the Michael J. Homer Family Fund, National Institutes of Health National Center for Research Resources University of California, San Francisco Clinical and Translational Science Institute grant UL1 RR024131, and the John Douglas French Alzheimer’s Foundation.
Differential Diagnosis Book
Author Contributions: Study concept and design: Paterson, Haman, Miller, and Geschwind. Acquisition of data: Paterson, Torres-Chae, Kuo, Ando, Nguyen, Wong, Haman, Johnson, and Geschwind. Analysis and interpretation of data: Paterson, Torres-Chae, DeArmond, Garcia, Johnson, and Geschwind. Drafting of the manuscript: Paterson, Torres-Chae, Haman, and Geschwind. Critical revision of the manuscript for important intellectual content: Paterson, Torres-Chae, Kuo, Ando, Nguyen, Wong, DeArmond, Garcia, Johnson, Miller, and Geschwind.
Statistical analysis: Paterson and Torres-Chae. Api standard 2510 pdf form. Obtained funding: Geschwind. Administrative, technical, and material support: Torres-Chae, Kuo, Wong, Haman, Garcia, Johnson, and Geschwind. Study supervision: Kuo, Haman, Miller, and Geschwind.
The majority of doctors are ill at ease when confronted by a patient with a neurological problem. Candidates for qualifying examinations and higher diplomas dread that they will be allocated a neurological 'Iong case'. This is a serious reflection on the adequacy of training in neurology. It is still possible in some medical schools for a student to go through the entire clinical course without an attachment to the neurological unit. Increasing competition for teaching time has led to the situation where in most US medical schools, and at least one new medical school in the UK, a two-week c1inical attachment to the neurology service is considered adequate. Those fortunate enough to attend a postgraduate course find a minimum of 3 months' intensive training is necessary before any confidence in tackling a neurological problem is achieved. Unfortunately, neurological textbooks seldom seem to recognize the intensely practical nature of the subject.
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There are many short texts that achieve brevity by the exclusion of explanatory material; these are difficult to read and digest. At the opposite extreme are the neurological compendia, often unbalanced by excessive coverage of rare diseases and all based on the assumption that patients announce on arrival that they have a demyelinating, heredofamilial, neoplastic etc. These texts are useful only to those who already have a good working knowledge of neurological diseases.